Andrew W. Zimmerman
Editor
Kennedy Krieger Institute and Johns Hopkins University,
Baltimore, Maryland
Contents
Part I Molecular and Clinical Genetics. . . . . . . . . . . . . . . . . . . . . . . . . . 1
1 ENGRAILED2 and Cerebellar Development in the Pathogenesis of
Autism Spectrum Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
Ian T. Rossman and Emanuel DiCicco-Bloom
2 Teratogenic Alleles in Autism and Other Neurodevelopmental
Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41
William G. Johnson, Madhura Sreenath, Steven Buyske and
Edward S. Stenroos
3 Cholesterol Deficit in Autism: Insights from Smith–Lemli–Opitz
Syndrome . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69
Alka Aneja and Elaine Tierney
4 Autism in Genetic Intellectual Disability
Insights into Idiopathic Autism. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81
Walter E. Kaufmann, George T. Capone, Megan Clarke and
Dejan B. Budimirovic
Part II Neurotransmitters and Cell Signaling . . . . . . . . . . . . . . . . . . . . . 109
5 Serotonin Dysfunction in Autism . . . . . . . . . . . . . . . . . . . . . . . . . . . . 111
Mary E. Blue, Michael V. Johnston, Carolyn B. Moloney and
Christine F. Hohmann
6 Excitotoxicity in Autism
The Role of Glutamate in Pathogenesis and Treatment . . . . . . . . . . . 133
Martin Evers and Eric Hollander
7 Prenatal b2-Adrenergic Receptor Signaling and Autism:
Dysmaturation and Retained Fetal Function . . . . . . . . . . . . . . . . . . . 147
Susan L. Connors
Part III Endocrinology, Growth, and Metabolism . . . . . . . . . . . . . . . . . 183
8 A Role for Fetal Testosterone in Human Sex Differences
Implications for Understanding Autism . . . . . . . . . . . . . . . . . . . . . . . 185
Bonnie Auyeung and Simon Baron-Cohen
9 Interaction between Genetic Vulnerability and Neurosteroids in
Purkinje cells as a Possible Neurobiological Mechanism in Autism
Spectrum Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 209
Flavio Keller, Roger Panteri and Filippo Biamonte
10 Insulin-Like Growth Factors
Neurobiological Regulators of Brain Growth in Autism? . . . . . . . . . . 233
Raili Riikonen
11 Oxidative Stress and the Metabolic Pathology of Autism . . . . . . . . . 245
S. Jill James
Part IV Immunology, Maternal-Fetal Interaction, and
Neuroinflammation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 269
12 The Immune System in Autism
Is There a Connection?. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 271
Luke Heuer, Paul Ashwood and Judy Van de Water
13 Maternal Immune Activation, Cytokines and Autism. . . . . . . . . . . . . 289
Paul H. Patterson, Wensi Xu, Stephen E.P. Smith and
Benjamin E. Devarman
14 Maternal Antibodies and the Placental–Fetal IgG Transfer Theory. . 309
Christina M. Morris, Mikhail Pletnikov, Andrew W. Zimmerman
and Harvey S. Singer
15 Can Neuroinflammation Influence the Development of Autism
Spectrum Disorders? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 329
Carlos A. Pardo-Villamizar
Part V Neuroanatomy and Neural networks . . . . . . . . . . . . . . . . . . . . . . 347
16 The Significance of Minicolumnar Size Variability in Autism
A Perspective from Comparative Anatomy. . . . . . . . . . . . . . . . . . . . . 349
Manuel F. Casanova
17 Imaging Evidence for Pathological Brain Development in Autism
Spectrum Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 361
Stephen R. Dager, Seth
18 Information Processing, Neural Connectivity, and Neuronal
Organization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 381
Nancy J. Minshew, Diane L. Williams and Kathryn McFadden
Part VI Environmental Mechanisms and Models . . . . . . . . . . . . . . . . . . 407
19 Evidence for Environmental Susceptibility in Autism
What We Need to Know About Gene Environment Interactions. . . 409
Isaac N. Pessah and Pamela J. Lein
20 An Expanding Spectrum of Autism Models
From Fixed Developmental Defects to Reversible Functional
Impairments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 429
Martha R. Herbert and Matthew P. Anderson
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 465
mediafire
http://adf.ly/IsFYv
Editor
Kennedy Krieger Institute and Johns Hopkins University,
Baltimore, Maryland
Contents
Part I Molecular and Clinical Genetics. . . . . . . . . . . . . . . . . . . . . . . . . . 1
1 ENGRAILED2 and Cerebellar Development in the Pathogenesis of
Autism Spectrum Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
Ian T. Rossman and Emanuel DiCicco-Bloom
2 Teratogenic Alleles in Autism and Other Neurodevelopmental
Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41
William G. Johnson, Madhura Sreenath, Steven Buyske and
Edward S. Stenroos
3 Cholesterol Deficit in Autism: Insights from Smith–Lemli–Opitz
Syndrome . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69
Alka Aneja and Elaine Tierney
4 Autism in Genetic Intellectual Disability
Insights into Idiopathic Autism. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 81
Walter E. Kaufmann, George T. Capone, Megan Clarke and
Dejan B. Budimirovic
Part II Neurotransmitters and Cell Signaling . . . . . . . . . . . . . . . . . . . . . 109
5 Serotonin Dysfunction in Autism . . . . . . . . . . . . . . . . . . . . . . . . . . . . 111
Mary E. Blue, Michael V. Johnston, Carolyn B. Moloney and
Christine F. Hohmann
6 Excitotoxicity in Autism
The Role of Glutamate in Pathogenesis and Treatment . . . . . . . . . . . 133
Martin Evers and Eric Hollander
7 Prenatal b2-Adrenergic Receptor Signaling and Autism:
Dysmaturation and Retained Fetal Function . . . . . . . . . . . . . . . . . . . 147
Susan L. Connors
Part III Endocrinology, Growth, and Metabolism . . . . . . . . . . . . . . . . . 183
8 A Role for Fetal Testosterone in Human Sex Differences
Implications for Understanding Autism . . . . . . . . . . . . . . . . . . . . . . . 185
Bonnie Auyeung and Simon Baron-Cohen
9 Interaction between Genetic Vulnerability and Neurosteroids in
Purkinje cells as a Possible Neurobiological Mechanism in Autism
Spectrum Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 209
Flavio Keller, Roger Panteri and Filippo Biamonte
10 Insulin-Like Growth Factors
Neurobiological Regulators of Brain Growth in Autism? . . . . . . . . . . 233
Raili Riikonen
11 Oxidative Stress and the Metabolic Pathology of Autism . . . . . . . . . 245
S. Jill James
Part IV Immunology, Maternal-Fetal Interaction, and
Neuroinflammation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 269
12 The Immune System in Autism
Is There a Connection?. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 271
Luke Heuer, Paul Ashwood and Judy Van de Water
13 Maternal Immune Activation, Cytokines and Autism. . . . . . . . . . . . . 289
Paul H. Patterson, Wensi Xu, Stephen E.P. Smith and
Benjamin E. Devarman
14 Maternal Antibodies and the Placental–Fetal IgG Transfer Theory. . 309
Christina M. Morris, Mikhail Pletnikov, Andrew W. Zimmerman
and Harvey S. Singer
15 Can Neuroinflammation Influence the Development of Autism
Spectrum Disorders? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 329
Carlos A. Pardo-Villamizar
Part V Neuroanatomy and Neural networks . . . . . . . . . . . . . . . . . . . . . . 347
16 The Significance of Minicolumnar Size Variability in Autism
A Perspective from Comparative Anatomy. . . . . . . . . . . . . . . . . . . . . 349
Manuel F. Casanova
17 Imaging Evidence for Pathological Brain Development in Autism
Spectrum Disorders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 361
Stephen R. Dager, Seth
18 Information Processing, Neural Connectivity, and Neuronal
Organization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 381
Nancy J. Minshew, Diane L. Williams and Kathryn McFadden
Part VI Environmental Mechanisms and Models . . . . . . . . . . . . . . . . . . 407
19 Evidence for Environmental Susceptibility in Autism
What We Need to Know About Gene Environment Interactions. . . 409
Isaac N. Pessah and Pamela J. Lein
20 An Expanding Spectrum of Autism Models
From Fixed Developmental Defects to Reversible Functional
Impairments . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 429
Martha R. Herbert and Matthew P. Anderson
Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 465
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http://adf.ly/IsFYv